Long-term trends in incidence, mortality and burden of liver cancer due to specific etiologies in Hubei Province.

Age–period–cohort analysis The age incidence pattern of liver cancer is almost the same for LCHB, LCHC and LCOC, while liver cancer caused by alcohol use showed a decreasing trend after the age of 75–80, with incidence rates of LCHB > LCHC > LCAU > LCOC in all age groups (Fig. 1 ).

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The ASIR showed an increasing trend across liver cancer groups in male, but remained stable in all female liver cancer groups.

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