Nonetheless, an association between changes in the methylation level of the CREB-regulated transcription coactivator 1 ( CRTC1 ) gene and early weight gain following psychotropic treatment initiation was shown [ 21 ], and a positive trend for increased methylation of protein kinase B ( AKT2) associated with insulin resistance was observed in patients treated with atypical antipsychotics, while the opposite correlation was revealed in mood stabilizer users [ 22 ].
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DNA methylation may partly explain psychotropic drug-induced metabolic side effects: results from a prospective 1-month observational study.
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