Higher PD-1/Tim-3 expression on IFN-γ+ T cells is associated with poor prognosis in patients with acute myeloid leukemia.

Our previous findings have reported an increasing trend toward PD-1+CD4+ T cells in PB in AML. 8 Interestingly, a higher percentage of PD-1+IFN-γ+CD4+ T cells was found, indicating that PD-1/PD-L1 pathways may impact CD4+ T cell function through the tumor-infiltrating inflammatory cytokines IFN-γ. 33 Further comparative analysis of different patterns of PD-1 and Tim-3 on IFN-γ+ T cells found that PD-1 and Tim-3-mediated T cell exhaustion were principally involved in Th1 rather than Tc1, with Tim-3 mainly in the form of co-expression with PD-1.

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