We performed biolayer interferometry (BLI) experiments, finding an overall trend consistent with increased human ACE2 (hACE2) affinity for the XBB.1.5 RBD compared with XBB.1, although in our experimental setup this difference did not reach the threshold for statistical significance (Supplementary Fig. 2A ).
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Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein.
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