Bone turnover change after randomized switch from tenofovir disoproxil to tenofovir alafenamide fumarate in men with HIV.

In the TAF group, there was a nonsignificant trend toward improvement in lumbar spine BMD compared to TDF (predicted increase compared to TDF of 2.0% [95% CI: 0.0-- 4.0, P = 0.06], Table 2 , Figure 4Sb-c [see Figure, Supplemental Digital Content 7, lumbar spine BMD changes]). total hip BMD showed no overall change in either group (Table 2 , Figure 5Sb-c [see Figure, Supplemental Digital Content 8, total hip BMD changes]).

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LS-BMD changes were slightly more favorable with TAF but failed to reach significance (TAF +1.7% [0.3,3.1], TDF -0.3 [-1.8,1.2], P = 0.06).

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