Regions targeted for hypomethylation during B cell maturation showed highly significant enrichment for the following six transcription factor families: activator protein 1 (AP-1), early B-cell factor (EBF), runt-related transcription factor (RUNX), octamer-binding transcription factor (OCT), interferon regulatory factor (IRF), and NF-kB [ 20 ].
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The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review.
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