ASO Author Reflections: Neoadjuvant Radiotherapy in Locally Advanced Esophageal Adenocarcinoma; Low-Dose Radiation, Low-Dose Expectations?

5 The difference may not be significant in SCC, but patients with AC treated with the low-dose regimen appear to have lower chances in obtaining pCR. 5 Although patient survival is not necessarily correlated with pCR and the risk of added radiation-related morbidity (for doses > 55 Gy) needs to be considered, complete clinical/pathological response after CRT becomes an increasingly relevant outcome per se.

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