However, in desma −/− ;desmb −/− ;fhl2a −/− ;fhl2b −/− quadruple mutant zebrafish EOMs, a highly significant increase in both cell death and proliferation was observed (Fig. 3e, h ).
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fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles.
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