Decay of HCoV-OC43 infectivity is lower in cell debris-containing media than in fresh culture media.

In this case, log-transformed data were fitted to a linear regression model, resulting in an estimated decay rate of d = -0.0310 ±0.0037 h -1 ( R 2 = 0.549, F 1,57 = 69.510, P < 0.001). Interestingly, the loss of infectivity in cell-free media was 3.35-fold faster compared to that in a media containing cell lysates, being the difference between both conditions highly significant ( t 78 = 32.925, P < 0.001).

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