PRDM16 co-operates with LHX2 to shape the human brain.

We found 449 genes common to both DEG sets of mouse Lhx2 cko and PRDM16 mutant organoids, which is highly significant based on hypergeometric statistics showing a representation factor 55.3 with a P -value < 0.00001 (see Methods) ( Supplementary Fig. 4D ).

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