A tick saliva serpin, IxsS17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent.

Likewise, there is an apparent trend (P < 0.1) that the spirochete load in 0.06 and 0.125 μM r Ixs S17 injected mice was 1.8 and 2.3 folds higher than the B . burgdorferi only group in ear tissues ( Fig 10C ).

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