Among the genes with the most pronounced alterations, the strongest sex-dimorphic changes were observed for Aldoc , which displayed a highly significant decreased expression in male astrocytes (FDR = 9.2E−39, logFC = −0.28), and a significantly increased expression in female astrocytes (FDR = 1.9E−39, logFC = 0.27).
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Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations.
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