Synthetic biology approach revealed enhancement in haeme oxygenase-1 gene expression by codon pair optimization while reduction by codon deoptimization.

Ann Med Surg (Lond) · 2024 · PMC10923308 · PMID 38463112

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highly significantno p-value reported

In contrast, only codon-deoptimized construct demonstrated highly significant changes in codon efficiencies compared to native sequence in all tissues.

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