Synaptic Terminal Density Early in the Course of Schizophrenia: An In Vivo UCB-J Positron Emission Tomographic Imaging Study of SV2A.

In the SCZ group, there was a significant negative relationship between hippocampal [ 11 C]UCB-J V T and the PANSS total score ( r = −0.48, p = .03) ( Figure 2 ; Table S2 ) and a nonsignificant trend toward a negative relationship for V T with positive ( r = −0.42, p = .06) and general ( r = −0.42, p = .06) but not negative PANSS subscale scores ( Figures S1–S3 ).

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