Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans.

While no such association was observed for older males, a highly significant sex-specific effect was observed when comparing female with male G -allele carriers ( P = 0.0006).

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For the study population, both young adults (ages 19–54 years; n = 100; TT = 61, G -allele carriers = 39) and older adults (ages 55+ years; n = 124, TT = 69, G -allele carrier = 55), carriage of the G -allele was associated with a borderline significant retention of FOXO3 expression as a function of age (Fig. 3a , younger participants: P = 0.02; Fig. 3b : P = 0.08).

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