Iron quantification in basal ganglia: quantitative susceptibility mapping as a potential biomarker for Alzheimer's disease - a systematic review and meta-analysis.

Specifically, the pooled SMD indicated a highly significant increase in iron in the PUT (SMD = 1.23, 95% CI = 0.62 to 1.84, p = 0.00, I 2 = 87.24%, k = 8, n = 208) ( Figure 3 ), nearly high increases in the GP (SMD = 0.79, 95% CI = 0.07 to 1.52, p = 0.03, I 2 = 88.88%, k = 6, n = 155) ( Figure 4 ), and moderate increases in the CN (SMD = 0.72, 95% CI = 0.39 to 1.06, p = 0.00, I 2 = 47.22%, k = 6, n = 152) ( Figure 5 ).

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