Immunofluorescence analyses of synaptic puncta indicated that IL-6 led to a significant reduction of the density of pre-synaptic puncta and colocalized puncta, and an almost significant defect in the post-synaptic puncta ( Figures 6 I‒6L).
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<i>Mecp2</i> knock-out astrocytes affect synaptogenesis by interleukin 6 dependent mechanisms.
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