Identification of both HSC and sinusoidal markers ( Pecam1 , Vwf , Cd9 ) among highly significant genes for PP in these animal models supports previous reports on the involvement of the vascular microenvironment in the development of hemodynamic alterations. 32 , 33 , 34 Furthermore, both cirrhosis- and CPA-linked genes comprised a vast number of matrix turnover genes, as well as angiogenesis genes (e.g . , Adam8 , Itgav , Vegfa , Pdgfa , Vcan ).
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Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension.
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