These structural changes in stereocilia, evident in OHCs by P6 but not yet in IHCs, likely explain the near-equal levels of ABR thresholds in P1- and P5-treated ears, while a slight (though not yet significant) increase in OHC-related DPOAE thresholds was observed after P5 delivery of Clrn2 compared to P1 injections.
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Clarin-2 gene supplementation durably preserves hearing in a model of progressive hearing loss.
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