Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging.

To test that these cell types are similar and can be used in a combined analysis, we correlated the transcriptional profiles of GM09503 cells with cells from individuals in age group 1 (correlation coefficient R = 0.96, p ‐value <2.2e‐16) and the transcriptional profiles of GM08401 with age group 5 ( R = 0.95, p ‐value <2.2e‐16), resulting in highly significant correlation coefficients; see Figure S17 . 4.5 Definition of age groups A hierarchical clustering approach was used to define five age groups.

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