Routine evaluation of HBV-specific T cell reactivity in chronic hepatitis B using a broad-spectrum T-cell epitope peptide library and ELISpot assay.

1 a, acute resolved patients (median 83 SFUs) displayed the highest numbers of reactive HBV-specific T cells while CHB patients (median 46 SFUs) showed the lowest ones among the R, CHB, LC and HCC groups, and an increasing trend of SFU numbers was found from CHB to LC and HCC groups.

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Furthermore, the numbers of HBsAg-, HBpol-, HBx-, or HBeAg-specific T cells also showed a decreasing trend similar to that of total HBV-specific T cells when HBV DNA, HBsAg, HBeAg and ALT levels gradually increased (Additional file 1 : Fig.

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