Synergistic Anti-Cancer Effects of ERB-041 and Genistein through Estrogen Receptor Suppression-Mediated PI3K/AKT Pathway Downregulation in Canine Mammary Gland Tumor Cells.

However, when treated with genistein alone or cotreated, the Bax/Bcl-2 ratio increased by approximately 30% and 143%, respectively, compared to that in the control group, which was highly significant ( Figure 3 C and Figure S2 ).

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