First-in-Class Humanized Antibody against Alternatively Spliced Tissue Factor Augments Anti-Metastatic Efficacy of Chemotherapy in a Preclinical Model of Pancreatic Ductal Adenocarcinoma.

To address the potential physiological significance of neutrophil count normalization by hRabMab1+gem/PTX in the PaCa-44 model, we performed correlation analysis between circulating neutrophil counts and tumor volumes across all 4 cohorts; a highly significant positive correlation between neutrophil counts and tumor volumes was identified (R = 0.628, p = 0.00002), mirroring findings reported in human patients [ 22 ].

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