ChemRAP uncovers specific mRNA translation regulation via RNA 5' phospho-methylation.

For example, in MDA-MB-231 triple-negative breast cancer cells depleted for BCDIN3D down to 20–30% of control cells, tRNA His levels, 5′-Pme modification, or aminoacylation are unaffected, yet these cells display significant changes in their transcriptome, proteome, and metabolome, as well as a highly significant reduction of their tumorigenic phenotypes both in cells and in vivo (Reinsborough et al, 2021 ; Xhemalce et al, 2012 ).

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