Cationic Vitamin E-TPGS Mixed Micelles of Berberine to Neutralize Doxorubicin-Induced Cardiotoxicity via Amelioration of Mitochondrial Dysfunction and Impeding Apoptosis.

Molecules · 2024 · PMC10935258 · PMID 38474668

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Moreover, the observed markedly significant reduction in the ratio of Bax/Bcl2 elevated levels in the cells exposed to a DOX challenge and co-treated with Brb-loaded cationic mixed micelle indicates the pivotal role of mitochondrial selectivity in enhancing the mitohormetic effects of Brb to mediate cardiovascular cellular resilience. 4.

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