Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.

We found a highly significant negative correlation between individual tumor scores in these bulk tumor tissue along a MYC–PRC axis, with PDS1 tumors displaying high-MYC–low-PRC target expression and PDS3 tumor displaying low-MYC–high-PRC target expression, and PDS2 tumors being intermediate (Fig. 5c and Extended Data Fig. 5g ).

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