Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells.

In our in vitro study, we evaluated the proliferation of three CRC cell lines, CT26.WT, DLD-1, and SW480, before and after IFN-γ stimulation using Cell Counting Kit-8 (CCK-8) assays and found that the absorbance value showed a decreasing trend in the IFN-γ stimulation group compared with the control group (without cytokine stimulation).

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