Functional enrichment analysis indicated that the 8824 SET-26 and HCF-1 commonly-bound genes were enriched for many biological processes, with the most highly significant being mitochondrial metabolism (253 genes), mRNA processing (214 genes), and ribosome subunits (82 genes) (Fig. 1i ; Supplementary Data 2 ).
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The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans.
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