Placental Pathology Contributes to Impaired Volumetric Brain Development in Neonates With Congenital Heart Disease.

3 Comparable to our results, Schlatterer et al did not find significant correlations between abnormal placentation and brain injury, but did observe a statistical trend toward more severe brain lesions in cases with placental abnormalities. 19 Although placental pathology may not directly cause postnatal brain injury, it could have an indirect effect, since reduced volumetric growth has been associated with increased susceptibility to postnatal brain injury. 6 Previous studies in other neonatal populations at risk for brain injury have reported associations between placental abnormalities and brain damage.

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