highly significantp-value < 0.01
The GSVA revealed that eight HALLMARK pathways showed statistically significant differences (p-value < 0.05) between different groups in the integrated dataset: ALLOGRAFT REJECTION and PANCREAS BETA CELLS pathways exhibited highly significant expression difference (p-value < 0.01) between PI and control groups, while G2M CHECKPOINT, GLYCOLYSIS, HEDGEHOG SIGNALING, IL2 STAT5 SIGNALING, NOTCH SIGNALING, and TGF BETA SIGNALING pathways showed statistically significant expression differences (p-value < 0.05) between the groups.