Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space.

Of note, a combination of C77A (or C77S) and C95A (or C95S) further limited FGF2 secretion to background levels in a highly significant manner, suggesting that both C77 and C95 play important but most likely different roles in unconventional secretion of FGF2 from cells.

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