Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo.

Both groups of mRNAs containing either AUG- or NCC-initiated uORFs exhibit very small, albeit highly significant, reductions in CDS TEs in the eIF2AΔ mutant versus WT cells in the absence of SM ( Figure 6A(i)–(ii) , columns 5 and 8 versus 2); however, the same was not observed for the effects of eIF2AΔ in SM-treated cells where eIF2 function is attenuated ( Figure 6(i)–(ii) , columns 6 and 9 versus 3).

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