Trends in pharmacotherapy utilization among patients with heart failure with preserved ejection fraction.

7.6 %, p < 0.01) showed fluctuating utilization rates for ARAs between 2008 and 2020, whereas female patients showed an increasing trend in utilization rates (6.6 % vs. 8.9 %, p < 0.01), similar to the trend observed in the main analysis ( Fig. 3 ).

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[13] , [19] In the present study, we observed an increasing trend in the utilization of ARBs after 2013 but a decreasing trend in the use of ACEI; thus we analyzed these categories separately.

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