On the other hand, OSI plasma C trough and pulmonary EGFRm + inhibition exhibited a decreasing trend but no significant change when CYP1A2 activity increased to 1.5-fold (approximately 1.55-fold higher in enzyme activity caused by smoking).
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Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach.
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