Gene Therapy for Dopamine Dyshomeostasis: From Parkinson's to Primary Neurotransmitter Diseases.

34 All four studies undertook post‐gene therapy fluoro‐m‐tyrosine (FMT)‐positron emission tomography (PET) analysis with a 25%–75% increase in putaminal uptake and an increasing trend with higher dosages. 30 , 31 , 32 , 35 One study reported 18Fluorodopa (18F‐DOPA) PET studies in 10 trial participants, demonstrating a 13%–79% increase in enzyme activity, with a trend toward greater increases in higher dose cohorts. 34 There were serious adverse event (AEs) re

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