Electrically stimulated in vitro heart cell mimic of acute exercise reveals novel immediate cellular responses to exercise: Reduced contractility and metabolism, but maintained calcium cycling and increased myofilament calcium sensitivity.

1 , 41 In fact, we rather observed a weak trend to increased intracellular Ca 2+ release, especially at higher stimulation frequencies, and moreover, we observed clear myofilament Ca 2+ sensitization in the intracellular [Ca 2+ ] range where the in vivo contraction occurs, 1 with marked exaggeration in the lowest [Ca 2+ ] where early‐phase contraction occurs, following acute exercise.

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