Health-related quality of life during the COVID-19 pandemic: The impact of restrictive measures using data from two Dutch population-based cohort studies.

18–59 year-olds with a medical risk condition showed an overall declining pattern up until November 2021, whereafter an increasing trend was observed.

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We do see a decreasing trend in physical health from January to April 2022, which is during the first and second Omicron wave when many infections occurred, possibly indicating that SARS-CoV-2 infections led to a decrease in physical health on the short-term.

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