When 14M and 24M datasets were further analyzed to evaluate highly significant common genes irrespective of their thematic clustering (FDR ≤0.05, FC ≥ ±2.0), 11 genes including Pgf , Ntrk2 , Pifo , Sez6l , Fabp5 , Podn , Slit1 , Nme5 , Elmod1 , Drc1 and Plppr1 were noted ( Supplementary Figure S7 ).
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Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine.
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