Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema.

rCBF significantly decreased after mild water intoxication (Figure 2c bottom , e, g) in both genotypes, reaching a plateau of −44.6 ± 3.5% and −35.6 ± 3.96% already within 15 min., with a small and marginally significant difference between the genotypes in accumulated rCBF reduction after WI (+7.56 ± 3.49% in WT compared to Aqp4 −/− , p = .04, Figure 2e ).

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