Successive tendon injury in an <i>in vivo</i> rat overload model induces early damage and acute healing responses.

MMP-3 expression had an increasing trend in group 1, followed by reductions in expression levels in subsequent groups, with no significance.

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While YAP expression increased 3.1-fold for group 1 and had a decreasing trend for the remaining groups, TAZ initially was upregulated by 2.1-fold and continued to increase ( Figure 3D ). 3.4 Cellular damage indicated early apoptotic processes Tenocytes in the control group had the characteristic elongated cell shape with cell extensions into the network of collagen fibrils ( Figures 4A, B ).

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