highly significantP < 0.001
* P < 0.05 was considered significant; ** P < 0.01 represents a highly significant difference between groups; and ** P < 0.001 represents an extremely significant difference between groups.
* P < 0.05 was considered significant; ** P < 0.01 represents a highly significant difference between groups; and ** P < 0.001 represents an extremely significant difference between groups.