Protective potential of outer membrane vesicles derived from a virulent strain of <i>Francisella tularensis</i>.

The levels of 10 cytokines changed in response to OMVs predominantly on day 14 post-treatment, followed by a decreasing trend on day 42 ( Figure 5 ).

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There was an obvious trend in increased secretion of IL-1β, IL-6, IL-10, IL-5, IL-17, IL-23, G-CSF, IL-3, and IFN-γ on day 14 after the OMVs immunization compared to the mock-treated mice.

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