The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2.

To characterize the antitumor effect of combined chemotherapy and PD-L2 antibody, we analyzed lymphocytic infiltration using IHC in residual tumors at 13 weeks of age and observed a highly significant increase of CD8 + T cells, but not CD4 + T cells ( Fig. 5b , c ).

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