In addition, under CLP condition, TIGIT + CD4 + T cells have significantly higher expression level of IFN-γ than their TIGIT - counterparts, while TIGIT + CD8 + T cells only show an increasing trend for IFN-γ expression ( Supplementary Figures 1A–D ).
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TIGIT regulates CD4<sup>+</sup> T cell immunity against polymicrobial sepsis.
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