Out of the five studies including LEDD as a prognostic factor for falls, three studies concluded that future fallers tend to have higher initial doses of levodopa [ 22 , 39 , 52 ], and one study concluded that the proportion of fallers with LEDD < 500 at baseline was significantly smaller [ 10 ], whereas in the remaining study [ 31 ] the daily LEDD was near significance for predicting recurrent fallers.
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Prognostic factors for falls in Parkinson's disease: a systematic review.
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