Microcirculation-driven mitochondrion dysfunction during the progression of experimental sepsis.

An increasing trend was observed in CO data until the 16th h (P < 0.001), and then CO dropped significantly below the level of the sham-operated animals at the 20th h (P < 0.001).

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HI was significantly higher in the 16–28 h time window with a decreasing trend in the septic group, but still being significantly higher compared to the sham-operated group at the 28th h (P 28h = 0.003; Fig. 2 c).

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