Absence of the Klotho Function Causes Cornea Degeneration with Specific Features Resembling Fuchs Endothelial Corneal Dystrophy and Bullous Keratopathy.

Our present results, however, do not show a significant increase in Wnt-1 expression with the Klotho null mutation, although an increasing trend is detected.

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The accumulation of 8-OHdG was found to be highly significant in all three regions of the cornea under the influence of the Klotho null mutation, when comparing with those of the wild types and the heterozygotes ( Figure 8 C–E).

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