HOXC9 characterizes a suppressive tumor immune microenvironment and integration with multiple immune biomarkers predicts response to PD-1 blockade plus chemotherapy in lung adenocarcinoma.

Overall, while the efficacy of PD-1 blockade exhibited a positive trend over Hoxc9 knockdown, statistical significance was not achieved.

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PD-L1 expression demonstrated an increasing trend among responders, the expressions of HOXC9 and FOXP3 displayed a decreasing trend, but statistically insignificant.

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