Transforming Growth Factor Beta 2 (TGFB2) mRNA Levels, in Conjunction with Interferon-Gamma Receptor Activation of Interferon Regulatory Factor 5 (IRF5) and Expression of CD276/B7-H3, Are Therapeutically Targetable Negative Prognostic Markers in Low-Grade Gliomas.

High Levels of TGFB2, IFNGR2, and Downstream Signaling Molecules Exhibited Worse OS Outcomes than Those of the Remaining Patients We next sought to characterize the upregulation of TGFB2 and IFNGR2 mRNA that was accompanied by highly significant correlations with worse OS in the population of LGG patients ( Figure 2 ).

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