Intravenous MSC-Treatment Improves Impaired Brain Functions in the R6/2 Mouse Model of Huntington's Disease via Recovered Hepatic Pathological Changes.

R6/2-PBS mice was highly significant ( p < 0.0001) ( Figure 4 A,B).

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Three of six analyzed genes ( Cyp1a , Cyp3a11 and Cyp3a41 ) had significantly decreased or increased expression levels in R6/2 mice compared to WT littermates, whereas both Cyp2b9 ( p = 0.0709) and Cyp2a4 ( p = 0.0975) genes showed a trend toward significance between R6/2 mice and WT controls ( Figure 1 C).

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